Cytokinetics Inc. (CYTK) and GlaxoSmithKline PLC (GSK) have agreed to end their cancer-drug collaboration and license agreement on Feb. 28, a move the biopharmaceutical company said "reinforces" the company's push to focus on internal research related to muscle function.

But investors weren't buying that rationale, sending its stock down 17% after-hours to $2.60. The stock through the close was up 9.8% this year.

Cytokinetics said Wednesday that it would seek to license its portfolio of three drug candidates so "they can be advanced in further clinical trials." The company recently decided to discontinue oncology research.

President and Chief Executive Robert Blum said, "We appreciate the opportunity we have had to collaborate with GlaxoSmithKline over the last eight years and we look forward to the possibility of advancing these novel oncology drug candidates into next stages of clinical development with another partner."

For its non-cancer operations, Cytokinetics has Amgen Inc. (AMGN) as a partner on a heart-failure treatment. There were rumors earlier this year that Amgen was eyeing the development-stage biotechnology company for a takeover. They have been denied by Cytokinetics.

 
   -By Kevin Kingsbury, Dow Jones Newswires; 212-416-2354; kevin.kingsbury@dowjones.com 
 
 
 
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