By Yuliya Chernova 

Twice a week, Andrey Zyuzin leaves his main office at Cisco Systems Inc. in the center of Moscow to work out of one of Cisco's outposts in a futuristic building on the city outskirts.

By now, Mr. Zyuzin, director of corporate affairs at Cisco Russia, was supposed to be working full time in the government-funded Skolkovo technology hub. Instead, the foundation of the building that will contain his future office is just being laid.

"There are carcasses of new buildings," said Mr. Zyuzin of the view he has from his temporary outpost in the HyperCube--the 27-million square-foot development's only completed building so far.

Skolkovo was once touted by government officials as a budding version of Silicon Valley that would help Russia transition from its oil-and-gas economy and into a diversified, technologically driven future. Around 2010, foreign venture investors and tech companies began stepping up their investment in Russia as the government seemed ready to align with the West.

The atmosphere has changed.

Skolkovo, conceived as a project that would attract a lot of international investment and knowledge, has faded from the agenda of the Russian government. More broadly, the interest from the government in collaborating with the West's technology sector lessened sharply. Concurrently, the West's passion for Russian technology sector has also cooled.

The conflict with Ukraine, new laws limiting the freedom of Internet users and companies, sanctions imposed on Russia, and official rhetoric focused on disengagement with the West, all have ratcheted up the risk of doing business in the country.

Western venture firms have sharply decreased investment this year, choking off funding for startups. Some Russian technology startups have fled the country altogether.

"We'll never say never, but the bar just went up even higher," said Sonali De Rycker, partner at Accel Partners, a Silicon Valley venture firm that made several large investments in Russia in the past few years but isn't planning to make any new ones anytime soon.

Other big firms have followed a similar path.

New York-based Bessemer Venture Partners allocated $20 million to Skolkovo projects in early 2012 to spend over the following two years but has spent none of it. Brian Feinstein, partner at Bessemer, said that the firm hasn't found the right opportunity in Russia. He stopped attending Skolkovo investment advisory board meetings last year, because the trips to Moscow no longer fit his schedule, he said. Mr. Feinstein said Bessemer will continue evaluating investments in Russia.

European firm Index Ventures, meanwhile, didn't take part in a $150 million funding round earlier this year for e-commerce company Ozon Holdings Inc., which has been called "Russian's Amazon," after investing prominently in earlier rounds.

As for Skolkovo, construction has been delayed. HyperCube, the futuristic building where Cisco's outpost is located, opened in 2013, and remains the lone active structure around. Original plans called for about 10,000 people to work and live in Skolkovo by the beginning of this year, but for now there are just 2,500, all commuters.

Startups that accepted Skolkovo grants--roughly $400 million so far, allocated to 259 companies--were required by law to move into offices there by the start of 2014, but when it became clear that their offices wouldn't be ready by then, the law was amended to change the deadline to the start of 2016.

Skolkovo's price tag rose from $4 billion to $8 billion, and $2 billion is still needed from private investors to get the main part of the project done, said Anton Iakovenko, general director for ODAS Skolkovo, a group responsible for the hub's construction.

Mr. Zyuzin said Cisco remains committed to Russia and to Skolkovo.

More than construction delays, though, the idea of technological reform and cooperation with the West now seems to be set in reverse.

Back in 2010, when then-President Dmitry Medvedev visited Silicon Valley to meet with tech companies such as Apple Inc. and Google Inc. and tout the Skolkovo project, he spoke of cooperation between the countries, of Russia being "eager to be an open country" in terms of investment, trade and collaborative projects. Russia needed to learn from the American experience, he said.

That talk contrasts with recent comments by Vladimir Putin--who again became president in 2012--calling the Internet a CIA project and criticizing Yandex NV, Russia's biggest online search company, for having European and American representatives among its managers.

"The new idea is disintegration [with the West]," said Serguei Beloussov, who has started several technology companies in Russia and is an investor at venture fund Runa Capital. "This project doesn't jibe" with the new politics and is no longer a major priority of the government, he said of Skolkovo. One of Mr. Beloussov's companies, Parallels, has received a Skolkovo grant valued at $5.5 million, and is set to move parts of its operations to the complex once it is completed.

Vasily Belov, senior vice president for innovations development at the Skolkovo Foundation--a nonprofit overseeing Skolkovo's development--played down the recent upheaval.

He said Russian investors in August were due to close four rounds of venture-capital funding in startups that accepted Skolkovo grants, which he said was similar to last year's numbers.

Several laws that passed in recent years have made technology companies feel unwelcome in Russia, some entrepreneurs and investors say. One allows the government to ban websites with objectionable information; another, which passed this year and has yet to be implemented, would require Russian Internet user data to be stored on servers located in Russia only.

As a result of the changed circumstances, some Russian startups and venture investors have packed up and relocated out of the country, and others are considering that option.

In May, Alexey Sheremetyev, the founder of home-décor app Planner 5D, moved from Moscow to Vilnius, Lithuania, in search of visa-free access to customers and partners in Europe. He said the situation for startups in Russia has worsened since he moved.

"I feel pressure and the pressure is rising," said Alexander Galitsky, managing partner at Moscow-based venture-capital firm Almaz Capital and a board member of the Skolkovo project who is now exploring moving his team out of Russia entirely. In late July, the European Bank for Reconstruction and Development, which invested billions in Russia, including into Almaz Capital, said it was freezing all investments there.

Anton Gladkoborodov, an entrepreneur who launched several high-profile startups in Russia, rented a room in an artist's studio in Manhattan's Chinatown in July and hired two people for his short-video-creation startup Coub, whose website draws 50 million unique users monthly.

The rest of his team is still in Moscow, but Mr. Gladkoborodov is strategizing on how to move them too. "Tomorrow the borders may close," he said in July. "Tomorrow we might start a war with Ukraine, and by extension the world. Tomorrow, my website may be shut down...No one knows."

Some investors see opportunities in Russia's startup slowdown.

"The Russian venture market is down...there's less competition, and many good projects at good valuations," said Lev Leviev, an investor and the co-founder of VKontakte, one of Russia's largest social networks.

Nick Shchetko contributed to this article.

Write to Yuliya Chernova at yuliya.chernova@wsj.com

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