By Tess Stynes 
 

Celgene Corp. (CELG) agreed to acquire 1.1 million shares of Acceleron Pharma Inc. (XLRN) from selling shareholders for about $47 million, which will raise the biopharmaceutical giant's stake in the small-drug developer to 14.8%, according to a regulatory filing.

Acceleron shares rose 16% to $39.36 in early trading. The stock has more than doubled from its September initial public offering price of $15.

Celgene is Acceleron's collaboration partner on two investigational treatments for cancer and other diseases. According to Acceleron's website, the company has received $75 million from Celgene in upfront payments from the two programs and is eligible to receive up to a combined $567 million in milestone payments.

Since early 2011, nearly a dozen young biotechs such as Acceleron have soared to valuations of $1 billion or more thanks to skyrocketing share prices -- even though almost none of the high-flyers even has a commercial product yet.

Public-market investors, having witnessed the growth of top biotechs such as Celgene, have been searching for the next great drug developer and are attracted to the promise of these young companies' experimental drugs.

Meanwhile, major drugmakers have been searching for new drugs to replace sales from treatments that have lost market exclusivity. In addition to their own research efforts, big drug companies have been entering collaborations and partnerships, as well as making acquisitions of smaller companies with promising drug pipelines.

Celgene owned nearly 3.5 million, or 11.29% of Acceleron's stock as of Jan. 28, according to FactSet Research.

The selling holders are Advanced Technology Ventures, Flagship Ventures, Polaris Venture Partners, Venrock, and Alkermes Inc., all of whom invested in the Acceleron before its IPO.

Write to Tess Stynes at tess.stynes@wsj.com

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