By Tess Stynes 
 

Advaxis Inc. (ADXS) reached a collaboration agreement with Amgen Inc. (AMGN) to advance the biotech drug developer's preclinical investigational cancer immunotherapy in a deal potentially valued at $540 million.

Princeton, N.J.-based Advaxis's shares rose 26% to $10.71 in early trading.

Under the agreement, Thousand Oaks, Calif.-based Amgen received exclusive global rights to develop and commercialize the personalized immunotherapy--known as ADXS-neo--which aims to activate a patient's immune system to fight unique mutations found in the individual's tumor.

Advaxis will receive an upfront payment of $40 million and is eligible for milestone payments of as much as $475 million. Amgen also will buy $25 million worth of Advaxis stock.

Like many other drugmakers, Amgen has been counting on introductions of new medicines, along with cost-cutting, as some of the company's older biotech drugs face competition from lower-priced treatments.

 

Write to Tess Stynes at tess.stynes@wsj.com

 

(END) Dow Jones Newswires

August 02, 2016 10:13 ET (14:13 GMT)

Copyright (c) 2016 Dow Jones & Company, Inc.
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