By Tess Stynes 

Amgen Inc. said its earnings, excluding restructuring charges, increased more than expected in the third quarter, driven by strong growth of key drugs such as cancer therapy Krypolis and osteoporosis treatment Prolia.

The strong results helped prompt Amgen to raise its guidance for the year.

Once a biopharmaceutical pioneer, Amgen as been facing challenges more typical for traditional drug makers, such as slowing sales of older drugs and the threat of low-cost competition. In July, Amgen also joined the ranks of major pharmaceutical companies that have been cutting jobs and closing plants. Amgen's restructuring plans included a 12% to 15% reduction in its global workforce and the closure of plants in two states.

Amgen said during a conference call with investors and analysts that it had finished the reorganization and exceeded its target of eliminating 2,900 jobs.

Amgen plans to provide details on its long-term growth strategy, restructuring efforts and drug pipeline at its business review meeting in New York on Tuesday.

The company also recently came under pressure from activist investor Dan Loeb, whose Third Point LLC has built a stake in the company and called for a potential split into two separate businesses. The New York hedge-fund noted its stock trades at a significant discount to peers, even though Amgen has a "compelling mix" of established and new products. Third Point urged Amgen to increase the efficiency of its research and development process, make deeper cost cuts and suggested most of the company's recent deals would produce "mediocre returns."

In all, Amgen reported a profit for the quarter of $1.24 billion, or $1.61 a share, down from $1.37 billion, or $1.79 a share, a year earlier. Excluding restructuring- and acquisition-related charges and other items, earnings rose to $2.30 from $1.94. Revenue increased 6% to $5.03 billion.

Analysts polled by Thomson Reuters expected a per-share profit of $2.11 and revenue of $4.96 billion.

Last year, Amgen bought Onyx Pharmaceuticals Inc. for $10.4 billion, gaining its flagship product, Kyprolis. The drug was approved in the U.S. in 2012 as a treatment for a blood cancer known as multiple myeloma.

In the third quarter, Kyprolis sales were $94 million, an increase of 21% from $78 million in the second quarter.

Sales of Amgen's osteoporosis drugs also improved thanks to stronger volume. Prolia sales surged 43% from a year earlier to $255 million, while Xgeva sales grew 22% to $318 million.

Combined sales of Neulasta and Neupogen, both of which are used to prevent infections in patients receiving chemotherapy, fell 6.7% to $1.49 billion. Neulasta sales increased 5% to $1.19 billion, mostly driven by pricing. However, Neupogen sales fell 36%, which Amgen mainly attributed to a $155 million order in the year-earlier period from the U.S. government.

Neupogen is facing generic competition in the U.S. from Teva Pharmaceutical Industries Ltd., which launched similar treatment Granix late last year. Amgen said underlying demand for both drugs was slightly hurt by competition.

As for the year, Amgen now expects earnings of $8.45 to $8.55 on revenue of $19.8 billion to $20 billion, up from its previous estimate for a per-share profit of $8.20 to $8.40 on revenue of $19.5 billion to $19.7 billion.

Jonathan D. Rockoff contributed to this article.

Write to Tess Stynes at tess.stynes@wsj.com

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