U.S. stocks were poised for a lower open Wednesday after disappointing results from technology heavyweights Apple Inc. and Microsoft Corp.

S&P 500 futures slipped 11 points, or 0.5%, to 2103. E-mini Dow futures lost 69 points, or 0.4%, to 17796. E-mini Nasdaq-100 futures dropped 63 points, or 1.4%, to 4603. Changes in stock futures don't always accurately predict moves after the opening bell.

After the bell on Tuesday, Apple posted a 38% surge in profit and said it sold 35% more iPhones in the fiscal third quarter compared with a year earlier. But Apple's iPhone sales missed some analysts' estimates and the company indicated its revenue in the current quarter could come in below Wall Street forecasts. Shares fell 6.9% in premarket trading.

Swings in Apple's shares can spark big moves in the major stock indexes. As the largest company by market capitalization in the S&P 500 and Nasdaq, Apple has an outsize impact on the two market-cap weighted indexes. Apple is among the companies with the highest stock prices in the Dow, which gives it major sway over the price-weighted blue-chip index.

"Not only is it a huge company, there are a lot of companies that depend on Apple for their businesses," said Chris Gaffney, president of EverBank World Markets. "With future demand possibly not as strong, we saw those shares get hurt overseas," he added.

Declines in technology shares Wednesday helped drag European stock markets lower. One of the biggest decliners in Europe was a company that designs basic chip technology that is found in more than 95% of all smartphones, including the iPhone. France's CAC-40 slipped 0.6% and Germany's DAX lost 0.9%. Asian shares were also mostly lower.

Microsoft Corp. reported a $3.2 billion quarterly loss in its fiscal fourth quarter on Tuesday afternoon, its biggest quarterly loss ever. Shares fell 3.9% in premarket trading.

In other earnings news, Coca-Cola Co. on Wednesday said profit jumped 20% in its second quarter as the beverage giant posted volume growth. Results topped expectations, pushing shares up 1% premarket.

Including results from 96 companies in the S&P 500, earnings are on track to fall 3% from a year ago. Ahead of the reporting season, analysts had forecast a 4.5% decline.

U.S. stocks fell Tuesday. The Dow lost 1% to 17919.29 and the S&P 500 slipped 0.4% to 2119.21. The Nasdaq Composite lost 0.2% to 5208.12, snapping a three-session winning streak.

The slump in commodities continued Wednesday. Gold futures declined 1.5% to $1087.50 an ounce. Crude-oil futures fell 1.4% to $50.17 a barrel.

The yield on the 10-year Treasury note slipped to 2.332% from 2.342% on Tuesday. Yields fall as prices rise.

Write to Saumya Vaishampayan at saumya.vaishampayan@wsj.com

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