International stocks trading in New York were mixed on Wednesday.

The BNY Mellon index of American depositary receipts eased 0.14% to 147.96. The European index edged up 0.31% to 144.57, the Asian index edged down 0.86% to 156.35, the Latin American index fell 1.26% to 232.63 and the emerging markets index decreased 1.02% to 275.22. Anheuser-Busch InBev NV (BUD, ABI.BT) was among the companies with ADRs that traded actively.

Anheuser-Busch InBev rose 2.3% to $119.88 after the world's largest brewer reported that a derivatives gain pushed its first-quarter earnings higher, helping offset weak demand in the U.S.--its largest market-- and the impact of a strong dollar on revenue from the rest of its global beer empire.

BHP Billiton's shareholders voted overwhelmingly in favor of a breakup of the mining giant into two different companies. But its soon-to-be-listed spinoff, known as South32, will start life in a tougher environment than when the plan was first mooted last year. More than 98% of BHP's shareholders voted at meetings in London and Perth, Australia, to support the split, which will move unwanted assets in commodities such as aluminum, nickel and manganese into South32. ADRs of BHP Billiton Ltd. (BHP, BHP.AU) fell 1.2% to $51.41 and ADRs of BHP Billiton PLC (BBL, BLT.LN) decreased 1.1% to $48.54.

ADRs of Prudential PLC (PUK, PRU.LN, 2378.HK, K6S.SG) fell 41 cents to $48.92 after the U.K.-based insurer and asset manager reported that growth in Asia continued to push up sales during the first quarter but that the strong performance was offset by falling profits in its U.K. and U.S. businesses.

GlaxoSmithKline PLC (GSK, GSK.LN) cut the amount of money it plans to return to shareholders under an asset swap with Switzerland-based Novartis AG (NVS, NOVN.VX). The U.K.-based drug maker also reported stronger first-quarter earnings, which were boosted by proceeds from the deal. Glaxo ADRs rose nearly 1% to $46.02. Novartis ADRs fell 54 cents to $101.63.

Even before this week, plans for a multibillion-dollar IPO of a vast chain of gas stations owned by Beijing-based China Petroleum & Chemical Corp. (SNP, 0386.HK, 600028.SH), known as Sinopec, had only been grinding slowly ahead. Now, the deal is unlikely to happen at all this year, following the retirement Monday of Fu Chengyu, the firm's high-profile chairman, The Wall Street Journal reported. ADRs fell 2.6% to $91.71.

Write to Tess Stynes at tess.stynes@wsj.com

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