LONDON (Thomson Financial) - GlaxoSmithKline PLC. has announced hundreds of people will lose their jobs when it closes its factory in Sussex in 2011, the BBC reported citing a company spokesman. Some 493 people are expected to be affected when the multinational drugs company's Crawley site closes. The company blamed the closure on "declining volumes, regulatory delays and patent expiries". A spokesman said production at the site would continue until the products had been moved to alternative facilities. The spokesperson said: "GSK sincerely regrets the potential impact of this proposal in terms of job losses and will do all it can to help staff through this difficult period. "Implementation of this proposal will be subject to consultation with trade union and staff representatives at the Crawley site. This process will begin immediately." The factory currently produces medicines to treat Parkinson's disease, heart disease, HIV/AIDS, bacterial skin infections, depression, and hypertension. tf.TFN-Europe_newsdesk@thomsonreuters.com slm COPYRIGHT Copyright Thomson Financial News Limited 2008. All rights reserved. The copying, republication or redistribution of Thomson Financial News Content, including by framing or similar means, is expressly prohibited without the prior written consent of Thomson Financial News.