International stocks trading in New York were mixed on Thursday. The Bank of New York index of American depositary receipts fell 0.1% to 156.34. The European index decreased 0.27% to 155.58, the Asian index improved 0.27% to 149.34, the Latin American index rose 0.09% to 291.27 and the emerging-markets index increased 0.36% to 289.75. Among the companies with shares that actively traded was Barclays PLC (BCS, BARC.LN).

Major brokers are shutting down their connections to a dark pool run by Barclays PLC (BCS, BARC.LN) after the New York Attorney General on Wednesday filed a lawsuit accusing the bank of fraud, The Wall Street Journal reported. The civil suit alleged that Barclays lied about how it favors high-frequency players in the firm's stock-trading business. Broker-dealers including Deutsche Bank AG (DB, DBK.XE), Royal Bank of Canada (RY, RY.T) and ITG have removed connections to the dark pool, called Barclays LX, from their routing systems, according to the Journal. Barclays shares fell 7.4% to $14.55. Deutsche Bank shares fell 2.7% to $35.51.

AstraZeneca PLC (AZN, AZN.LN) said an advisory committee to the U.S. Food and Drug Administration voted against accelerated approval of a ovarian cancer drug in the U.S. The decision dealt a blow to its new drug-development pipeline, an important plank of its defense in fighting off a $120 billion approach from Pfizer Inc. (PFE) last month. The FDA isn't obliged to follow the panel's recommendations, although it often does. AstraZeneca shares fell 0.3% to $74.13.

Siemens AG (SIEGY, SIE.XE) applied for U.S. Food and Drug Administration approval for its 3-D breast tomosynthesis system. Earlier this week, the technology--which scans breasts from multiple angles to create a 3-D image--got a big boost when a much-publicized study found them more accurate than regular digital scans. Currently only Hologic Inc.'s (HOLX) 3-D system has FDA approval. General Electric Co. (GE) completed its application last July. Siemens shares fell 1.4% to $131.57.

Statoil (STO, STL.OS) signed a preliminary agreement with Oslo-based oil supplier Kvaerner ASA (KVAER.OS) for the 3 billion Norwegian kroner ($489 million) delivery of two steel substructures to the Johan Sverdrup oil field, one of the country's biggest-ever developments, a sign that high-cost suppliers in Norway are slashing costs to win contracts. The deal comes after a number of offshore contracts have been awarded to cheaper Asian yards in recent years, and as Norwegian oil suppliers worry about Statoil's plans to cut spending. Shares fell 0.4% to $30.95.

Write to Tess Stynes at tess.stynes@wsj.com

Subscribe to WSJ: http://online.wsj.com?mod=djnwires