Amarin Corp PLC (AMRN) Quote

It would seem strange to include methamphetamines in a pharmaceutical drug, and try to hide it. 🤣

Colchicine has many serious side effects and would be dangerous to pair with Vascepa for long term use.

My source was a woman I work with. Also, another man at work says his wife started taking it and has been increasing her dosage. It’s like a Coca Cola addiction. It may not be noticeable at first until you stop drinking it.

I’m sure these drug companies don’t want you to know what’s in their products.

Captain,
There is no such thing as an International Patent.

This is simply an international application published under the patent cooperation treaty (PCT) which is managed by the World Intellectual Property Organization (WIPO) based in Geneva, Switzerland.

It is kind of a mailing box to reach the 133 states signatories + [ARIPO (Africa); Eurasian; European; OAPI(Americas)] Regional Protection and hence establish priority claim. It is similar to the one used for LR-EtEPA.

Amarin must then designate the countries and regions it wants to reach within a certain deadline (for most 31 months; for Europe 32 months) and initiate the process of applying for patent protection with them.

IM GOING TO AGM FOR 8AM.My wife is going to take a train and im going to talk because the guy in 2022 told me i couldnt talk ..90 fcuking cents I am on the war path

I recently came across this interesting International Patent issued to Amarin on 10/06/22 for the combination therapy of EPA + Colchicine (WO2022212655A1) to reduce the risk of cardiovascular events in subjects on statin therapy.

https://worldwide.espacenet.com/patent/search/family/083459738/publication/WO2022212655A1?q=ICOSAPENT%2C%20AMARIN

Colchicine is an ancient drug used since about 1500 BC for anti-inflammatory conditions. In 1961 the FDA approved colchicine to relieve symptoms associated with gout.

More recently, the Colchicine Cardiovascular Outcomes Trial (COLCOT NCT02551094) demonstrated a 25-30% reduction in CVE’s in ASCVD patients. The drug works by targeting Residual Inflammatory Risk.

In the future, combination therapy with lipid-lowering and anti-inflammatory medications” (like VASCEPA®/VAZKEPA®, my words), “may be used more frequently for patients with ASCVD.”

https://www.sciencedirect.com/science/article/abs/pii/S0735109723059600?via%3Dihub

Nuke, can you point to anything showing that those drugs contain methamphetamine?

I have not heard or read anything saying that.

I don't know if this has been discussed on this board or not? I've heard rumors that weight loss drugs like Ozempic and Wegovy has trace amounts of methamphetamine in it? That people taking it become addicted to it (Ozempic, Wegovy) by taking more and more everyday. I also didn't know these drugs were injected subcutaneously. If this is true, shame on you FDA for approving these drugs.

Thanks for that .NUMBER. on the AGM.I am going to the national Concert Hall just across the road from Authur Cox to listen to the music of Quency Jones same night .I have the wife with me but i cant see me getting to AGM as its 3 hours from Galway..i feel its not going to be good and every other AGM was in the afternoon and a mix of bankers and investors but it looks like they want to do this while we sleep.They should just say NO SHAREHOLDERS ALLOWED .But we own over 70%of the company .

sese333

How is it possible when you post almost EVERY day ? So you post but do not know what the PPS is daily come on man !!

Michael

Liam, At the Dublin offices of Arthur Cox LLP, ten Earlsfort Terrace, Dublin 2, DOT T380, Ireland, on April 18, 2024 at 9:00 AM local time.
Sleven,

Anyone know where and time of AGM.london or Dublin

Liam,
https://last10k.com/sec-filings/amrn/0000950170-24-024353.htm
I think I have the right company this time.
Sleven,

JRoon, Thanks. My bad.
Sleven,

Wrong Amarin

AGM? Anyone know details

https://amarincorp.com/investor-relations/events-and-presentations

I know what they are and I thought they had gone 30 days again under a dollar. At the very least I know we were darn close to the 30 days

At first I thought they were pre releasing earnings again but I guess not.

What date is AGM
Is it in London or Dublin .I was at it in 2022.Vry tough security getting in but they have to let shareholders .The room was jammed back in 2019 and I was the only one at it in 2022.

Amarin to Report First Quarter 2024 Financial Results and Host Conference Call on May 1, 2024

DUBLIN, Ireland and BRIDGEWATER, N.J., April 15, 2024 (GLOBE NEWSWIRE) -- Amarin Corporation plc (NASDAQ:AMRN) today announced that it will host a conference call with Patrick Holt, President & CEO, and members of Amarin’s senior management team to discuss its first quarter 2024 results followed by Q&A on Wednesday, May 1st, 2024, at 8:00 a.m. ET.

The conference call with management will follow the release of the Company’s first quarter 2024 financial results in the pre-market hours.

To enhance engagement with the company’s shareholder base and facilitate connections with its investors, Amarin is partnering with Say Technologies to allow retail and institutional shareholders to submit and upvote questions, a selection of which will be answered by Amarin management during the earnings call.

Starting on April 15th at 8:00 am ET, all shareholders are encouraged to submit questions by visiting: https://app.saytechnologies.com/amarin-2024-q1. This Q&A platform will remain open until 48 hours prior to the start of the earnings call. Shareholders can email support@saytechnologies.com for any support inquiries.

Conference Call and Webcast Information:

Access to the live call:
Go to the investor relations section of the Company's website at?www.amarincorp.com
Dial in within the United States: 888-506-0062
International dial in: 973-528-0011
Access Code: 207947

Access to replay:
Dial in within the United States: 877-481-4010
International dial in: 919-882-2331
Access Code: 50260

A replay of the call will also be available through the Company's website shortly after the call

Thanks Capt for the succint overview of the history and then the benefits of Vascepa. Some day soon hopefully the doctors will catch on and V will begin an upward direction for sales.
Like you continue to say, "It's the EPA Stupid!"

The recent historical status of TG’s (past 10-15 years) as a risk factor in CVD prevention is indeed interesting. Many here may recall that prior to the ANCHOR Trial the FDA had believed that TG reduction could be used as a surrogate for CVD Risk Reduction. Thus, they promised (in the SPA agreement), to approve VASCEPA for a CVD indication if ANCHOR achieved significant TG reduction.

Unfortunately, they changed their minds (in the “Infamous” ANCHOR ADCOM) after seeing the results of studies like AIM-HIGH, & THRIVE which showed TG reduction without CVD benefit. Since then, especially after STRENGTH & PROMINENT), TG’s have been looked at as a “Marker” more than a “Risk Factor”.

Unfortunately, the design of REDUCE-IT and EVAPORATE in order to mimic previous studies had to include elevated TG’s as an inclusion criteria. Subsequent subgroup analysis has shown that CVD benefit of VASCEPA is consistent within all TG levels. More recently at ACC24 last week, it was shown that the benefits of VASCEPA were irrespective of LDL-c, and Lp(a) levels. These all suggest that VASCEPA May work just as well alone (mono-therapy), without statins, and without a TG level criteria on the label.

Funny thing: even though TG >150 was an inclusion criteria in REDUCE-IT, MARINE, ANCHOR & EVAPORATE, it has since been estimated by Mason, Bhatt etal (if I recall correctly), that elevated TG’s only accounted for about 4.5% of the total Risk Reduction.

The pleiotropic pathways of VASCEPA go beyond Triglyceride Rich Lipoprotein’s and appear to be mostly (>83%) related to EPA serum levels!

It’s The EPA Stupid!

Thanks Marjac

Atherosclerosis evaluation and cardiovascular
risk estimation using coronary computed
tomography angiography
Received 7 October 2023; revised 13 February 2024; accepted 13 March 2024; online publish-ahead-of-print 12 April 2024

https://watermark.silverchair.com/ehae190.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAA3gwggN0BgkqhkiG9w0BBwagggNlMIIDYQIBADCCA1oGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMT8qrsdh6RuZxcv8_AgEQgIIDK-GkzLEuR6nEZBVD-rjUGlAqT1EvBfAIpt2fCzWzgALqX5EMOcpSB0zdHEriEjXu1EGFVNfcgFTp-fmg65LQe4zZwaO8EVr-c1DNY-sVjxL7ywA1E-VNSCPYUmjsAJdyHG3pAX3BVGVmzzKLTe1aaABz5UBeAAdi_CfD2RFXZI6puBuQymu9hHkN9tFPwT8Tam24ROkeFnt-fCf0HozvQ3br4vKBY3ALAbBRP7a6nRWvYxQ03aufomProTkIuU_98dUZvKbskek23VOc_4La7ZMQ80x3BUOy7XcE0iW08mu6_HexV0PWmLYZizerpUBeajcxpkJ0dJg-KofvSKem-uOIkik1eKyiqr-KqMjw83_s8TJ31xCCtfKaK2ekU-H4WpFAIFWcpzdj919FEtQQYHqZ4CVTO5FAVIYMqK0FYKHgn2fc2bpbStYKQTu7CChjZqE01s_fpDo8c6lfAu8uOqn1AWW9zDcrNboygkvQSZ7NyD1cyskYa2KIz0-Ucefmyezcjd7Gmv6RCjo8i_9nHIiYBnNviBEj5hX_Vo2rdeE5oDDIHsMvY5cblKshVpxo1D9NDvuA9L_0RkCAp_t9lNtxP65_ivr4JZm5aKB44A5J75vMq4nSNMZMvKZEgun10H4m9FWiTWxULPf_1ZxEk3cMzn4XNzvYMUVDFqVy88bR0hRg-vQzrGVCE-5CoOjFqAX7zhIM7Zl0UmMUpPMt0rNiOwr2JZrBRx3raaY-50qfPk6LMzeUO4V2Sukpge9QLcoFPo2ITWEUme9ibe3BdOzNJiH9p3ThbK4fqwddY1--tqIq4L8f0Nostqo7Pz3oe6PwYI2rF7rmlvXTaXdNPWaa31h1Lch1hbecoG8zOZNm2ASp5prYPfA9h_t-SpQ1fdw6xEfdM-6tF7x2HSzij3Fr9kGycvTr0lchMvXcS-HfxOFto_g8Q3NvokpQzrhvTniz-yJKKMwuPvrs8lxgyzaG4Mb4rDlPw5_I6kklNT7F973gjT-c5F7fN6uneWuQAE8Xur4_7eQSnqGQdU9Ajt6_vp81y17O0OipjM95nbCCQWZwHrMCDuRqCm8

It is jargon within the Clerk's Office for setting filing and hearing deadlines.

Interesting mention of Icosapent Ethyl. I am sure this is based on the Evaporate trial by Dr. Budoff. What caught my eye was the comment that it was only shown to reduce plaque in those with trigs above 150. So I did look up the Evaporate study and sure enough the median trig level was over 250. Of course this doesn't mean it couldn't help someone with lower trigs but just not proven in a trial:

Another drug, icosapent ethyl (Vascepa) has also been shown to reduce plaque, but only in people who have elevated triglycerides (higher than 150 milligrams per deciliter). Since your triglycerides are normal, it's not clear that this would help./quote]

https://www.health.harvard.edu/heart-health/treating-persistent-angina

https://www.linkedin.com/pulse/when-looking-published-cvots-only-prescription-ethyl-john-uqosc?utm_source=share&utm_medium=member_ios&utm_campaign=share_via

where is The AGM thursday in Dublin .Anyone

Eicosapentaenoic acid and docosahexaenoic acid suppress colonic tumorigenesis in obese mice
Received 10 January 2024, Revised 29 March 2024, Accepted 2 April 2024, Available online 9 April 2024, Version of Record 9 April 2024.
https://www.sciencedirect.com/science/article/pii/S175646462400166X?dgcid=rss_sd_all

Well stated.

Yes, it's frustrating. But if you take a few steps back and look, you can see what they are trying to do. And you can also recognize that it's going to take time. And it's not so much that it takes time to execute, but time for certain milestones to appear (we have to wait for the buyback, the lawsuits take time, results of trials take time, regulator approvals take time, etc.).

In the interim, it can be very frustrating, as you said, not knowing what's going on.

But, you also have to remind yourself that Sarissa has some sort of game plan or exit strategy. So they are likely not going to be satisfied just GIA in perpetuity without a commensurate rise in SP (or eventual BO).

Finally, the (hopeful) rise in SP is likely not going to be linear. If I had to guess, Sarissa likely wants to utilize momentum to build the stock price. Build one positive catalyst on top of another (along with aggressive, positive PR), and squeeze out shorts at the same time. My *hope* is that they can start to build this momentum around the stock buyback. But who knows.

Seve, I find it difficult to believe that you are actually that unaware of the NASDAQ noncompliance rules. You might want to read more and post less.
Sleven,

At this stage Amarin needs a compelling event to get going again.
I can see only a handful of events that can jump start this stock.

It is just frusturating it has been 13 months I thought we would be well over 2 a share by now maybe even over 3 a share. Instead we just have to hope Denner has all kids of stuff lined up he can unleash after the buyback, but its pure speculation. They don't say anything so we have no idea what they have lined up, if anything at all. Part of me fears what you see is what you get and its just going to be a very slow build up in Europe we have to wait on.

Nope. We went out then back in.

I thought we went out of compliance again and needed another 10 days over a buck. Today was day 8.

Seve, I think we are in a holding pattern for a while longer. On a day-to-day basis, not much is going to change in the short-term, and we will swing up and down in price until some of the factors we all know about begin to emerge.

Thanks Sleven

We’re already in compliance. It will take 30 days under $1.00 to get another letter. Chill!

JRoon, I post the updates with the hope that someone with a pacer account will unlock them. Even without the document being unlocked we still have some idea about what's going on. Today the judge gave us a schedule. Yesterday we got a date for an R&R.
Sleven,

Sleven, does someone have access to these documents? I see these links get posted all the time, but nobody seems to be able to access them.

https://www.courtlistener.com/docket/59859757/dr-reddys-laboratories-inc-v-amarin-pharma-inc/
Sleven,

But kind of specific to amarin. I have a bio up 300% in two months with no news at all. In fact it is even up today. 2024 was suppose to be the year the bios turned around but our little stock is going the wrong way once again. Seems the ceiling on AMRN is about 1.40 and then it gets driven back down. Will the buyback get it over 1.40? Who knows.

Fear not........ this dog will have it's day.....

sese333

What ?
at this point that we are under a buck and will now not regain compliance

Once the price went above $1 for 10 days they were in compliance The PPS would need to close under a $1 for 30 trading days to be considered not in compliance again then the clock starts for 6 months to regain compliance of a close of $1 for ten days. Don't get me wrong this sucks big time

Michael

Overall market has taken a drubbing the last few days and volume here is small so not Amarin specific. Steady as she goes. I am like the Dread Pirate Roberts, taking iocaine powder over time so I am now immune.

Oh Ralphey u so clever.hehehe

Just mind blowng at this point that we are under a buck and will now not regain compliance. Denner has a plan I am told but the goalposts always get moved each month. Now it is he wants the stockprice as low as possible for the buyback in two months is the new theory. Then once the buyback starts they will just start unleashing all this incredible news they are just sitting on.I suppose we are about due for a PR stating they think he SP is very undervalued. They have been in control over a year now and we are under a buck. But oh it is because they want it under a buck. That is jsut absurd logic imo.